Among the various DTI analytic methods, tract-based spatial statistics (TBSS) of fractional anisotropy (FA) values is an automated and sensitive technique that performs accurate voxel-based white matter analysis of multi-subject diffusion imaging data 14.ĭTI allows the evaluation of white matter tract integrity through its ability to image water diffusion characteristics 11, 12, 13. TBSS is a reliable and appropriate method that provides information on global changes in white matter microstructure 14. However, there are no TBSS-based reports on the relationship between PTA duration and the white matter integrity in TBI. In the current study, we investigated the relationship between the PTA duration and white matter integrity in TBI patients by undertaking TBSS.įorty-seven patients with TBI (22 men, 25 women mean age 45.21 ± 17.68 years range 20 ~ 79 years) and 47 age-and sex-matched normal control subjects (22 men, 25 women mean age 40.60 ± 12.49 years range 22 ~ 74 years) with no history of neurological/psychiatric disease were recruited to this study. The 47 patients with TBI were recruited according to the following inclusion criteria: (1) first-ever TBI, (2) age 20–79 years, (3) DTI scans obtained during the chronic stage (> 4 weeks after onset), and (4) no previous history neurologic/psychiatric disease. Those TBI patients with a continuous PTA state were excluded. Table 1 lists the demographic and clinical data of the patient and control groups.
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